NIBSC - Sequence Alignment

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Home Page > Spotlight > CJD Resource Centre > Available Samples > WHO Reference Reagents > NHBX0 - 0002 > Sequence Alignment

Sequence Alignment

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Sequence Alignment

The following alignment image image was generated after direct sequencing from PCR products using template genomic DNA extracted from the following homogenates;

Reference Code	Ref in image	Chr$
NHBX0/0001	Redcomposite	spCJD(M/M)
NHBX0/0002	Greencomposite	spCJD(M/M)
NHBY0/0003	Bluecomposite	nvCJD(M/M)
NHBX0/0004	Yellowcomposite	spCJD(M/V)
NHBZ0/0005	Clearcomposite	-ve ctrl(M/M)

Since these sequences represent data from a number of experiments (both + & -ve strand sequencing) the term composite is used to describe them.

mrna is a published prion sequence: AY008282.1 GI:11079225

Example of section of MV trace

prion gene MM example Example of section of MM trace

Prion gene codon 129 VV trace Example of section of VV trace