NIBSC - Serology Reagents

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Serology Reagents

NIBSC produces and distributes standards and reference materials for use in the calibration, validation or quality control of serological assays for microbiology targets. The range of reference reagents available comprises; WHO International Standards, reference panels, and working reagents. Specific information on the reagents listed below can be sourced via the product code hyperlink.

These can be purchased via the products page. For further information contact enquiries.

WHO International Standards

These reagents are produced under the WHO Biological Standardisation programme and are intended for the calibration of secondary reference materials and in the validation of NAT-based assays. They are not intended for routine use. The concentration of each reagent is assigned in International Units (IU). This is an arbitrary value, established by consensus following extensive international studies involving many laboratories. The supply of WHO International Standards is limited to five vials per laboratory per year in order to preserve stocks. The supply of WHO International Reference Panels is limited to two panels per laboratory per year.

Preparation	Type of Standard	NIBSC code
Anti-Canine Distemper Serum	1^st WHO International Standard	CDS
Anti-Canine Hepatitis Serum	1^st WHO International Standard	CHS
Anti Dengue, WHO Reference Panel	WHO Reference Panel	05/248
Anti-Dengue Virus Types 1+2+3+4, Human	WHO Reference Reagent	02/186
Anti-HBc (Anti-hepatitis B core antigen)	1^st WHO International Standard	95/522
Anti-HBs Immunoglobulin	2^nd WHO International Standard	07/164
Anti-Hepatitis A Immunoglobulin, Human	2^nd WHO International Standard	97/646
Anti-hepatitis E Serum, Human	WHO Reference Reagent	95/584
Anti-Newcastle Disease Serum	1^st WHO International Standard	NDS
Anti-parvovirus B19 plasma, human	2^nd WHO International Standard	01/602
Anti-rabies Immunoglobulin, Human	2^nd WHO International Standard	RAI
Anti-varicella zoster immunoglobulin	1^st WHO International Standard	W1044
Anti-Yellow Fever Serum, monkey	1^st WHO International Standard	YF
Hepatitis B surface antigen (HBsAg), subtype adw2, genotype A	2^nd WHO International Standard	00/588
Hepatitis B Surface Antigen, subtype adw2, genotype A	WHO Reference Panel	03/262

Link to retrovirology reagents

NIBSC Serology Working Reagents

NIBSC Serology Working Reagents are intended to be used as routine quality controls to monitor the performance of serological assays. It is for the user to assess the suitability of the material in their particular assay system.

The Result Reporting System (RRS) software is available free for on-line, real-time QA of all the products on this page.

For further information please contact ClinicalVirology@nibsc.hpa.org.uk.

Working reagent	NIBSC code	CE Marked
Anti Hepatitis C Virus	06/188	✔
Anti-HCV (1 in 8 dilution)	06/190	✔
Anti-Japanese Encephalitis (Anti-JE) Virus Control Plasma, Human	02/184
Anti-Japanese Encephalitis Virus Plasma, Human	02/182
Anti-Varicella-Zoster Antibody*	90/690	✔
Hepatitis B Surface Antigen 0.2 IU/ml*	07/288	✔
Hepatitis B Surface Antigen Monitor Sample 0.05IU*	07/286	✔

* Calibrated in IU against respective WHO International Standard

Link to retrovirology reagents

QCRU Serology Working Reagents

HPA quality control reagents are serological markers used to monitor reproducibility in diagnostic assays. They give a guide to internal quality performance and help to determine lot-to-lot variation between assays. The HPA supply a wide range of reagents for use with in-vitro diagnostic assays of: HIV, rubella, syphilis, Toxoplasma, hepatitis and more.

For more information please follow the link below:

http://www.hpa.org.uk/HPA/ProductsServices/InfectiousDiseases/QualityAssurance/1158313434385/